Common side effects of sulfonamide antibiotics include:

The correct response highlights a specific ocular side effect associated with sulfonamide antibiotics, which can induce a myopic shift in some patients. This phenomenon occurs due to the medication's effects on the lens and ciliary body, causing temporary refractive changes. Although it's less commonly discussed compared to other side effects, the myopic shift is indeed a notable concern in patients taking these medications.

In contrast, nausea and vomiting, rash, and headache are all common side effects associated with sulfonamides and other antibiotics. Nausea and vomiting can result from gastrointestinal irritation, while rashes are related to hypersensitivity reactions that sulfonamides can provoke. Headaches may arise from various mechanisms, including allergic reactions or general discomfort related to other side effects. However, these symptoms do not specifically highlight the unique ocular impact of sulfonamides as effectively as the myopic shift does. Therefore, the selection of myopic shift underscores a critical aspect of sulfonamide pharmacology that is particularly relevant in an optometric context.