Sulfadiazine is prescribed in combination with which drug to treat Toxoplasmosis?

Sulfadiazine is commonly prescribed in combination with pyrimethamine to treat Toxoplasmosis, particularly in immunocompromised patients such as those with HIV/AIDS. This combination is effective because both drugs target the parasitic infection from different mechanisms.

Pyrimethamine is an antiprotozoal agent that inhibits dihydrofolate reductase, an enzyme crucial for folate metabolism in the parasite, thereby impeding its ability to synthesize DNA and replicate. Sulfadiazine, on the other hand, is a sulfonamide that also interferes with folate synthesis by inhibiting the enzyme dihydropteroate synthase. When used together, these two drugs synergistically enhance the therapeutic effect and improve treatment outcomes for Toxoplasmosis.

This combination is well-established and often recommended in clinical guidelines for the management of this particular infection. In contrast, other options such as clindamycin, azithromycin, and tetracycline may have roles in treating different types of infections, but they are not the standard combination alongside sulfadiazine for Toxoplasmosis.