What condition are NSAIDs relatively contraindicated in?

Nonsteroidal anti-inflammatory drugs (NSAIDs) are relatively contraindicated in heart disease primarily due to their impact on the cardiovascular system. While NSAIDs are effective for pain relief and inflammation, they can cause fluid retention and increase blood pressure, which can exacerbate existing heart conditions. Additionally, some studies suggest a potential association between chronic NSAID use and an increased risk of heart attack and stroke, particularly in individuals with preexisting cardiovascular disease.

NSAIDs may pose particular risks to patients with heart disease, especially those with heart failure, where fluid overload is a concern. This makes the careful management of NSAID use essential for patients with heart conditions to avoid complications that can arise from their use.

While NSAIDs are also a concern in other conditions, such as kidney disease, liver disorders, and gastrointestinal ulcers, the specific relationship to heart disease and the direct risks it presents make it a notable contraindication for their use.