What generation of fluoroquinolone is Ofloxacin?

Ofloxacin is classified as a second-generation fluoroquinolone. This generation of fluoroquinolones is characterized by being more effective against a broader spectrum of gram-negative and some gram-positive bacteria compared to the first generation. Second-generation fluoroquinolones, including Ofloxacin, offer enhanced pharmacokinetic properties, which allows for better oral bioavailability and tissue penetration. They are commonly used to treat various infections, particularly those caused by aerobic gram-negative bacteria.

The third and fourth generations of fluoroquinolones have introduced further enhancements, especially in their activity against gram-positive bacteria and atypical pathogens, but Ofloxacin specifically belongs to the second generation due to its development timeline and the spectrum of activity it covers.