What is a common contraindication for the use of fluoroquinolones?

Fluoroquinolones are commonly contraindicated in pediatric populations primarily due to concerns about potential adverse effects on developing musculoskeletal systems. Studies have shown that fluoroquinolones can cause damage to cartilage, leading to issues such as musculoskeletal pain or conditions in children and adolescents. This is a significant consideration when prescribing these antibiotics, as the risk of joint damage in growing bones is especially pronounced.

In addition, the potential for serious side effects, such as tendon rupture and central nervous system effects, further raises caution in younger patients. As a result, the use of fluoroquinolones is typically limited in children unless no alternative treatments are available and the benefits significantly outweigh the risks. This precaution is especially important in the context of treating infections where safer alternatives exist.