What is combined with Trimethoprim to create Polytrim ophthalmic solution?

Polytrim ophthalmic solution is a combination of trimethoprim and polymyxin B, which is used as an antimicrobial agent for the treatment of bacterial conjunctivitis. Trimethoprim functions as a folic acid synthesis inhibitor, while polymyxin B acts by disrupting bacterial cell membrane integrity. This synergistic action provides a broad spectrum of activity against common pathogens that cause eye infections.

In this formulation, the combination enhances the overall effectiveness of the treatment compared to using each agent separately, as polymyxin B provides coverage against gram-negative organisms, while trimethoprim deals more with gram-positive organisms and some gram-negative bacteria. This type of combination is particularly beneficial in the ophthalmic field, where effective topical treatment is crucial for conditions like conjunctivitis.

This combination is specifically formulated for ophthalmic use, which distinguishes it from other potential partners that might not be suitable or approved for use in eye care.