What potential deficiency is associated with the use of Isoniazid?

Isoniazid, commonly used in the treatment of tuberculosis, can lead to a deficiency of Vitamin B6, also known as pyridoxine. This occurs because isoniazid interferes with the metabolism of Vitamin B6, specifically inhibiting the enzyme that converts pyridoxine to its active form, pyridoxal phosphate. This active form is essential for numerous metabolic processes, including the synthesis of neurotransmitters and the metabolism of amino acids.

By decreasing the availability of Vitamin B6, isoniazid can lead to various neurological issues and an increased risk of peripheral neuropathy, which is why healthcare providers often recommend supplementing Vitamin B6 for patients on isoniazid therapy. This relationship between isoniazid and Vitamin B6 plays a crucial role in monitoring and management during tuberculosis treatment to prevent deficiency-related complications.