Which antibiotic class is often considered a first-line treatment in pregnancy?

Cephalosporins are often considered a first-line treatment during pregnancy due to their safety profile and effectiveness against a variety of bacterial infections. They have a broad spectrum of activity and are generally well-tolerated. The pharmacokinetics of cephalosporins in pregnant patients align well with their therapeutic uses, allowing for effective treatment without significant risk to the developing fetus.

In contrast, other antibiotic classes have associated risks during pregnancy. Tetracyclines, for instance, can lead to tooth discoloration and affect bone development in the fetus, making them unsuitable for use in pregnant women. Fluoroquinolones are associated with potential risks such as cartilage damage in the developing fetus, and therefore their use is typically avoided. Aminoglycosides can have oto- and nephrotoxicity, presenting additional risks in pregnancy situations.

Given these considerations, cephalosporins stand out as a more appropriate choice for treating infections in pregnant patients, highlighting their role as a first-line option.