Which condition can result from increased usage of topical NSAIDs?

Topical NSAIDs (non-steroidal anti-inflammatory drugs) are commonly used to manage pain and inflammation, particularly in the context of ocular conditions. When these medications are used frequently, they can lead to corneal problems, which includes conditions such as corneal epithelial defects or corneal melting. The cornea is particularly sensitive to the effects of medications, and excessive use of topical NSAIDs can disrupt the normal healing processes and the integrity of the corneal epithelium.

The mechanism relates to the inhibition of cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins involved in protecting the corneal surface and regulating inflammation. When these protective factors are diminished due to frequent NSAID usage, adverse effects on the cornea become more likely.

While other conditions such as heart failure, cataracts, and neuropathic pain may be associated with various medications or underlying health issues, they are not directly linked to the increased usage of topical NSAIDs. Therefore, corneal problems emerge as the most relevant consequence of excessive topical NSAID use in this context.