Which drugs are associated with Whorl Keratopathy?

Whorl keratopathy, also known as vortex keratopathy, is a unique corneal manifestation associated with specific medications. The drugs listed in the correct answer, including chloroquine and hydroxychloroquine, are well known for causing this condition due to their accumulation in the epithelial cells of the cornea, leading to the characteristic whorled pattern. Amiodarone is another medication that causes whorl keratopathy, as it can lead to corneal deposits resulting from lipid accumulation. Indomethacin and tamoxifen have also been observed to cause this effect, making this combination particularly significant in clinical practice.

In contrast, the other options present medications that are less commonly associated with this specific corneal finding. Drugs listed in other choices, such as acyclovir and its derivatives, are primarily associated with other ocular side effects but not with whorl keratopathy. Antifungal agents like fluconazole and similar drugs primarily treat fungal infections and do not show a link to this corneal pattern. Additionally, while doxycycline, minocycline, and tetracycline are well-known antibiotics, they are not typically associated with the whorled corneal changes seen in keratopathy.

Therefore, the comprehensive understanding of the