Which effect is associated with the blockade of calcium channels by calcium channel blockers?

Calcium channel blockers primarily function by inhibiting the influx of calcium ions through L-type calcium channels, which has a direct impact on vascular smooth muscle and cardiac muscle. When these channels are blocked, the result is the relaxation of vascular smooth muscle, leading to vasodilation. This is particularly true for coronary arteries, where dilation allows for improved blood flow to the heart muscle itself.

Increased blood flow can alleviate conditions such as angina and is beneficial in various cardiovascular diseases. This mechanism is crucial because the heart requires a significant amount of oxygenated blood, especially during increased activity or stress. By dilating the coronary arteries, calcium channel blockers effectively reduce the workload on the heart and enhance oxygen delivery.

Thus, the dilation of coronary arteries is a key effect associated with the action of calcium channel blockers, fitting the context of their therapeutic use in managing hypertension and angina pectoris.