Which enzyme does Chloroquine inhibit to reduce inflammation?

Chloroquine reduces inflammation primarily through the inhibition of phospholipase A2. This enzyme plays a crucial role in the release of arachidonic acid from membrane phospholipids, which is a precursor for the production of various inflammatory mediators, including prostaglandins and leukotrienes. By inhibiting phospholipase A2, chloroquine decreases the availability of arachidonic acid, thus preventing the synthesis of these inflammatory agents and effectively reducing the inflammatory response.

This mechanism is particularly important in conditions where excessive inflammatory processes are present, such as in autoimmune diseases. The reduction in inflammatory mediators leads to a decrease in the overall inflammatory response and can help alleviate symptoms associated with chronic inflammatory conditions.