Which medication class is associated with increasing uveoscleral outflow?

Prostaglandin analogs are known for their ability to increase uveoscleral outflow, which is a critical mechanism in the reduction of intraocular pressure (IOP) commonly associated with glaucoma. These medications work by mimicking the action of natural prostaglandins in the body, leading to relaxation of the ciliary muscle and increased aqueous humor drainage through the uveoscleral pathway.

This class of medications has been widely studied and shown to effectively lower IOP, making them a first-line treatment option for patients with open-angle glaucoma. Their efficacy in enhancing uveoscleral outflow is contrasted with other medication classes. For example, beta-blockers primarily decrease the production of aqueous humor, while carbonic anhydrase inhibitors reduce aqueous humor production as well. Alpha agonists can have a dual mechanism but are not primarily focused on enhancing uveoscleral outflow.

Consequently, the distinctive action of prostaglandin analogs in improving uveoscleral outflow is why this medication class is the correct answer in this context.