Which of the following antibiotics is most often combined with clavulonic acid?

Amoxicillin is commonly combined with clavulanic acid to create a formulation that enhances its effectiveness against bacterial infections. Clavulanic acid is a beta-lactamase inhibitor that protects amoxicillin from being degraded by certain bacteria that produce beta-lactamase enzymes. These enzymes can inactivate many penicillins and cephalosporins, making the bacterial infections more difficult to treat.

By pairing amoxicillin with clavulanic acid, the spectrum of activity is broadened, making it effective against a wider range of bacteria, including those that would otherwise be resistant to amoxicillin alone. This combination is frequently used in clinical practice to treat various infections, including sinusitis, otitis media, and respiratory tract infections, where beta-lactamase-producing bacteria may be involved.

The other antibiotics listed do not typically utilize clavulanic acid in combination therapy. Ciprofloxacin and levofloxacin are fluoroquinolones that have their own mechanisms of action and do not require beta-lactamase inhibitors. Penicillin G is a natural penicillin that is not commonly combined with clavulanic acid, as it is not typically affected by the same range of beta-lactamase producing bacteria that would