Which of the following antifungals is broad-spectrum and available in a topical ophthalmic formulation?

Amphotericin B is recognized as a broad-spectrum antifungal agent that is used in the treatment of various fungal infections, particularly those caused by fungi that can lead to serious systemic infections. Its broad-spectrum efficacy is attributed to its ability to bind to ergosterol in fungal cell membranes, leading to membrane disruption and cell death.

In the context of antifungal treatments for eye infections, Amphotericin B is particularly notable for its formulation that allows for topical ophthalmic use. This allows it to be effectively delivered directly to the site of infection, making it highly relevant in treating ocular fungal infections. While Mengorrhizae ketoconazole and miconazole are also antifungals, they are less commonly used in a topical ophthalmic application. Griseofulvin, primarily used for dermatophyte infections, is not typically formulated for ocular use, highlighting Amphotericin B's unique position as both a broad-spectrum antifungal and suitable for topical ophthalmic application.