Which of the following conditions can be exacerbated by COX-2 activity?

COX-2 (cyclooxygenase-2) is an enzyme that plays a significant role in inflammation and pain. It is primarily induced during inflammatory responses and is responsible for producing prostaglandins that mediate inflammation. Therefore, the condition that can be exacerbated by COX-2 activity is inflammatory disorders.

In inflammatory disorders, COX-2 activity leads to an increase in prostaglandins that promote inflammation and pain. These prostaglandins can not only contribute to the symptoms associated with inflammatory conditions but can also enhance the inflammatory response itself. Consequently, medications that inhibit COX-2, such as selective COX-2 inhibitors, are often used to treat conditions like arthritis, where reducing inflammation is a key therapeutic goal.

The other options do not relate directly to the exacerbation by COX-2 activity in a similar manner. While gastrointestinal ulcers can be a result of COX-1 inhibition, leading to a decrease in protective gastric mucosal prostaglandins, they are not typically exacerbated by COX-2. Hypertension can be influenced by COX-2 activity, but the relationship is complex and not directly linked to exacerbation in the same way as inflammatory disorders. Allergic reactions are