Which of the following medications can cause pseudotumor cerebri?

Pseudotumor cerebri, also known as idiopathic intracranial hypertension, can indeed be associated with the use of certain medications, particularly hormonal contraceptives. The mechanism by which contraceptives contribute to this condition is not entirely understood, but it is believed to involve changes in fluid dynamics or hormonal variations affecting intracranial pressure.

Hormonal contraceptives can influence fluid retention and the body's vascular systems, leading to increased intracranial pressure in susceptible individuals. Additionally, the estrogen component of many contraceptive pills has been implicated in stimulating mechanisms that could lead to such increased pressure.

Other medications listed, such as NSAIDs, analgesics, and antihistamines, do not have a significant established link to the development of pseudotumor cerebri. While they can have various side effects, they do not typically contribute to increased intracranial pressure. Therefore, hormonal contraceptives stand out as the most relevant agents associated with this condition. Understanding these relationships is crucial as they can guide clinicians in managing and advising patients regarding the potential risks of their medications.