Which prostaglandin analog is most likely to cause conjunctival hyperemia?

Bimatoprost, marketed as Lumigan, is well-known for its ability to lower intraocular pressure, making it a common treatment for glaucoma. One of the notable side effects associated with bimatoprost is conjunctival hyperemia, which refers to increased blood flow to the conjunctiva, resulting in a red or flushed appearance of the eye. This occurs due to the specific mechanism of action of bimatoprost, which can cause vasodilation and increased blood flow in the conjunctival tissues.

In clinical practice, bimatoprost is often observed to lead to more significant levels of conjunctival hyperemia compared to other prostaglandin analogs, such as latanoprost and travoprost. While latanoprost (Xalatan) and travoprost (Travatan) can also cause conjunctival irritation or redness, the incidence and severity of this side effect are typically less pronounced than with bimatoprost. Unoprostone (Rescula), another prostaglandin analog, is less commonly associated with conjunctival hyperemia compared to the others mentioned.

Thus, among the choices provided, bimatoprost is the most likely prostaglandin analog to cause conjunctival hyperemia, making it the accurate selection