Which side effect of Pilocarpine can significantly impact a patient's daily life?

Pilocarpine is a muscarinic agonist primarily used to treat glaucoma by increasing aqueous humor outflow, which can help lower intraocular pressure. One notable side effect of pilocarpine is the occurrence of browaches, which can occur due to excessive contraction of the ciliary muscle as well as the sphincter pupillae. This muscle contraction can lead to discomfort and tension around the brow and forehead area.

Browaches are particularly impactful because they can interfere with a patient's daily activities, causing discomfort that may distract from tasks such as reading, driving, or working. The persistent nature of this discomfort can affect quality of life, leading to frustration and difficulty concentrating, which makes it a significant side effect compared to others.

While the other side effects, such as worsening of cataracts, frequent eye watering, and delayed pupil response, can have their own implications, they may not disrupt daily life to the same extent. Worsening cataracts generally occurs over an extended period, frequent eye watering can often be managed with tissue or adjustments in environment, and delayed pupil response might be less noticeable in a person's day-to-day activities. In contrast, the immediate and often uncomfortable nature of browaches can lead to significant disruption in a person's routine