Which three medications are classified as systemic alpha-1 antagonists?

The classification of systemic alpha-1 antagonists refers to medications that block alpha-1 adrenergic receptors, which is primarily associated with vasodilation and decreased peripheral resistance. The three medications identified in the correct answer—Tamsulosin, Terazosin, and Prazosin—are all recognized for their role in treating conditions such as hypertension and benign prostatic hyperplasia (BPH) by relaxing smooth muscle in the prostate and bladder neck, making it easier to urinate.

Tamsulosin is commonly prescribed for BPH because it is selective for the alpha-1A subtype found in the urinary tract, providing effective symptom relief with fewer blood pressure effects. Terazosin and Prazosin are also effective in lowering blood pressure and are utilized in managing hypertension and urinary symptoms associated with BPH. By blocking the alpha-1 receptors, these drugs lead to vasodilation and reduced vascular resistance.

The other options list medications that do not fit the classification of systemic alpha-1 antagonists. For instance, propranolol, atenolol, and metoprolol are beta blockers, which primarily block beta-adrenergic receptors and are used to manage cardiac conditions, not as alpha-1 antagonists. Labetal