Which two drugs are classified as Beta-1 specific antagonists?

Beta-1 specific antagonists are a class of medications that selectively block the beta-1 adrenergic receptors primarily located in the heart. This action leads to a decrease in heart rate, contractility, and overall cardiac output, making them useful in conditions such as hypertension, heart failure, and arrhythmias.

Atenolol and Metoprolol are both examples of Beta-1 specific antagonists. Atenolol selectively inhibits beta-1 receptors, producing effects such as lowering blood pressure and reducing the workload on the heart. Similarly, Metoprolol is a selective beta-1 blocker that is commonly used for its cardioprotective effects. Their specificity for beta-1 receptors minimizes effects on beta-2 receptors found in the lungs and vascular smooth muscle, reducing the risk of bronchoconstriction and other side effects commonly associated with non-selective beta-blockers.

In contrast, Carvedilol is a non-selective beta-blocker that also has alpha-1 blocking activity, while Propranolol is a non-selective beta-blocker that affects both beta-1 and beta-2 receptors. Bisoprolol, although a beta-1 selective antagonist, is not paired with Atenolol in the given